這個消息來源應該是二次轉載, 原文如下:
Mead S et al. 2009. A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure. The New England Journal of Medicine 361(21): 2056-2065.[網址]
Abstract
Background Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes. Its incidence has steadily declined since the cessation of its route of transmission, endocannibalism.
Methods We performed genetic and selected clinical and genealogic assessments of more than 3000 persons from Eastern Highland populations, including 709 who participated in cannibalistic mortuary feasts, 152 of whom subsequently died of kuru.
Results Persons who were exposed to kuru and survived the epidemic in Papua New Guinea are predominantly heterozygotes at the known resistance factor at codon 129 of the prion protein gene (PRNP). We now report a novel PRNP variant — G127V — that was found exclusively in people who lived in the region in which kuru was prevalent and that was present in half of the otherwise susceptible women from the region of highest exposure who were homozygous for methionine at PRNP codon 129. Although this allele is common in the area with the highest incidence of kuru, it is not found in patients with kuru and in unexposed population groups worldwide. Genealogic analysis reveals a significantly lower incidence of kuru in pedigrees that harbor the protective allele than in geographically matched control families.
Conclusions The 127V polymorphism is an acquired prion disease resistance factor selected during the kuru epidemic, rather than a pathogenic mutation that could have triggered the kuru epidemic. Variants at codons 127 and 129 of PRNP demonstrate the population genetic response to an epidemic of prion disease and represent a powerful episode of recent selection in humans.
其實這不是新聞, Kuru症在新幾內亞東部高地Fore族的遺傳性疾病學, 人類學上的重要性早在1960年代便有相當的研究, 可參閱中時電子報以及台大醫學院內之科普文章.
食人族有對付狂牛症基因？科學家驚訝
2009-11-19 新聞速報【中廣新聞／郭希誠】
英國研究人員發現，巴布亞紐幾內亞的食人族身體裡發展出了一種特別的基因，可以避免得俗稱狂牛症的庫賈氏症。
巴布亞紐幾內亞「東高地省」有個佛瑞族，有吃死去親人腦子的習俗。二十世紀中，大批族人得了一種類似狂牛症的腦部疾病喪生。政府禁止再吃人腦。
英國倫敦大學醫學研究會的米德教授分析佛瑞族的DNA以後發現，他們有一種特有的基因突變，能夠讓他們不會得到庫賈氏症。
依照佛瑞族長老的口述歷史，他們是二十世紀初才開始吃人腦的。科學家對人類可以在短短的幾十年就發展出一種基因對抗疾病，感到相當驚訝。
他們也希望這項發現對治療庫賈氏症有幫助。
Mead S et al. 2009. A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure. The New England Journal of Medicine 361(21): 2056-2065.[網址]
Abstract
Background Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes. Its incidence has steadily declined since the cessation of its route of transmission, endocannibalism.
Methods We performed genetic and selected clinical and genealogic assessments of more than 3000 persons from Eastern Highland populations, including 709 who participated in cannibalistic mortuary feasts, 152 of whom subsequently died of kuru.
Results Persons who were exposed to kuru and survived the epidemic in Papua New Guinea are predominantly heterozygotes at the known resistance factor at codon 129 of the prion protein gene (PRNP). We now report a novel PRNP variant — G127V — that was found exclusively in people who lived in the region in which kuru was prevalent and that was present in half of the otherwise susceptible women from the region of highest exposure who were homozygous for methionine at PRNP codon 129. Although this allele is common in the area with the highest incidence of kuru, it is not found in patients with kuru and in unexposed population groups worldwide. Genealogic analysis reveals a significantly lower incidence of kuru in pedigrees that harbor the protective allele than in geographically matched control families.
Conclusions The 127V polymorphism is an acquired prion disease resistance factor selected during the kuru epidemic, rather than a pathogenic mutation that could have triggered the kuru epidemic. Variants at codons 127 and 129 of PRNP demonstrate the population genetic response to an epidemic of prion disease and represent a powerful episode of recent selection in humans.
其實這不是新聞, Kuru症在新幾內亞東部高地Fore族的遺傳性疾病學, 人類學上的重要性早在1960年代便有相當的研究, 可參閱中時電子報以及台大醫學院內之科普文章.
食人族有對付狂牛症基因？科學家驚訝
2009-11-19 新聞速報【中廣新聞／郭希誠】
英國研究人員發現，巴布亞紐幾內亞的食人族身體裡發展出了一種特別的基因，可以避免得俗稱狂牛症的庫賈氏症。
巴布亞紐幾內亞「東高地省」有個佛瑞族，有吃死去親人腦子的習俗。二十世紀中，大批族人得了一種類似狂牛症的腦部疾病喪生。政府禁止再吃人腦。
英國倫敦大學醫學研究會的米德教授分析佛瑞族的DNA以後發現，他們有一種特有的基因突變，能夠讓他們不會得到庫賈氏症。
依照佛瑞族長老的口述歷史，他們是二十世紀初才開始吃人腦的。科學家對人類可以在短短的幾十年就發展出一種基因對抗疾病，感到相當驚訝。
他們也希望這項發現對治療庫賈氏症有幫助。
